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A concept of capillary active, dynamic insulation integrated with heating, cooling and ventilation, air conditioning system

Mark BOMBERG

《结构与土木工程前沿（英文）》 2010年第4卷第4期页码 431-437 doi: 10.1007/s11709-010-0071-9

摘要： When a historic fa?ade needs to be preserved or when the seismic considerations favor use of a concrete wall system and fire considerations limit exterior thermal insulation, one needs to use interior thermal insulation systems. Interior thermal insulation systems are less effective than the exterior systems and will not reduce the effect of thermal bridges. Yet they may be successfully used and, in many instances, are recommended as a complement to the exterior insulation. This paper presents one of these cases. It is focused on the most successful applications of capillary active, dynamic interior thermal insulation. This happens when such insulation is integrated with heating, cooling and ventilation, air conditioning (HVAC) system. Starting with a pioneering work of the Technical University in Dresden in development of capillary active interior insulations, we propose a next generation, namely, a bio-fiber thermal insulation. When completing the review, this paper proposes a concept of a joint research project to be undertaken by partners from the US (where improvement of indoor climate in exposed coastal areas is needed), China (indoor climate in non-air conditioned concrete buildings is an issue), and Germany (where the bio-fiber technology has been developed).

关键词： capillary active insulation integrated heating cooling and ventilation air conditioning (HVAC) and building enclosure dynamic insulation switchable thermal resistance variable U-value walls

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Distribution and removal of antibiotic resistance genes during anaerobic sludge digestion with alkaline, thermal hydrolysis and ultrasonic pretreatments

Mengli Wang, Ruying Li, Qing Zhao

《环境科学与工程前沿（英文）》 2019年第13卷第3期 doi: 10.1007/s11783-019-1127-2

摘要：

Sludge digestion is critical to control the spread of ARGs from wastewater to soil.

Fate of ARGs in three pretreatment-AD processes was investigated.

UP was more efficient for ARGs removal than AP and THP in pretreatment-AD process.

The total ARGs concentration showed significant correlation with 16S rRNA gene.

The bacteria carrying ARGs could be mainly affiliated with Proteobacteria.

关键词： Tetracycline resistance genes Sulfonamide resistance genes 16S rRNA gene Sludge pretreatment Anaerobic sludge digestion

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Functional flax fiber with UV-induced switchable wettability for multipurpose oil-water separation

《环境科学与工程前沿（英文）》 2022年第16卷第12期 doi: 10.1007/s11783-022-1588-6

摘要：

● A PAA-ZnO-HDTMS flax fiber with UV-induced switchable wettability was developed.

关键词： Flax fiber Switchable wettability ZnO-HDTMS coating Oil-water separation

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Thermal transport in organic/inorganic composites

Bin LIU, Lan DONG, Qing XI, Xiangfan XU, Jun ZHOU, Baowen LI

《能源前沿（英文）》 2018年第12卷第1期页码 72-86 doi: 10.1007/s11708-018-0526-6

摘要： Composite materials, which consist of organic and inorganic components, are widely used in various fields because of their excellent mechanical properties, resistance to corrosion, low-cost fabrication, etc. Thermal properties of organic/inorganic composites play a crucial role in some applications such as thermal interface materials for micro-electronic packaging, nano-porous materials for sensor development, thermal insulators for aerospace, and high-performance thermoelectric materials for power generation and refrigeration. In the past few years, many studies have been conducted to reveal the physical mechanism of thermal transport in organic/inorganic composite materials in order to stimulate their practical applications. In this paper, the theoretical and experimental progresses in this field are reviewed. Besides, main factors affecting the thermal conductivity of organic/inorganic composites are discussed, including the intrinsic properties of organic matrix and inorganic fillers, topological structure of composites, loading volume fraction, and the interfacial thermal resistance between fillers and organic matrix.

关键词： thermal conductivity organic/inorganic composites effective medium theory thermal percolation theory interfacial thermal resistance

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Steady-state thermal-hydraulic analysis of SCWR assembly

LIU Xiaojing, CHENG Xu

《能源前沿（英文）》 2008年第2卷第4期页码 475-478 doi: 10.1007/s11708-008-0093-3

摘要： Among the six gen-IV reactor concepts recommended by the gen-IV international forum (GIF), supercritical water-cooled reactor (SCWR), the only reactor with water as coolant, achieves a high thermal efficiency and, subsequently, has economic advantages over the existing reactors due to its high outlet temperature. A thermal-hydraulic analysis of the SCWR assembly is performed in this paper using the modified COBRA-IV code. Two approaches to reduce the hot channel factor are investigated: decreasing the moderator mass flow and increasing the thermal resistance between moderator channel and its adjacent sub-channels. It is shown that heat transfer deterioration cannot be avoided in SCWR fuel assembly. It is, therefore, highly required to calculate the cladding temperature accurately and to preserve the fuel rod cladding integrity under heat transfer deterioration conditions.

关键词： cladding temperature assembly temperature coolant resistance

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Prevalence of antifolate drug resistance markers in in China

《医学前沿（英文）》 2022年第16卷第1期页码 83-92 doi: 10.1007/s11684-021-0894-x

摘要： The dihydrofolate reductase (dhfr) and dihydropteroate synthetase (dhps) genes of Plasmodium vivax and antifolate resistance-associated genes were used for drug resistance surveillance. A total of 375 P. vivax isolates collected from different geographical locations in China in 2009–2019 were used to sequence Pvdhfr and Pvdhps. The majority of the isolates harbored a mutant type allele for Pvdhfr (94.5%) and Pvdhps (68.2%). The most predominant point mutations were S117T/N (77.7%) in Pvdhfr and A383G (66.8%) in Pvdhps. Amino acid changes were identified at nine residues in Pvdhfr. A quadruple-mutant haplotype at 57, 58, 61, and 117 was the most frequent (57.4%) among 16 distinct Pvdhfr haplotypes. Mutations in Pvdhps were detected at six codons, and the double-mutant A383G/A553G was the most prevalent (39.3%). Pvdhfr exhibited a higher mutation prevalence and greater diversity than Pvdhps in China. Most isolates from Yunnan carried multiple mutant haplotypes, while the majority of samples from temperate regions and Hainan Island harbored the wild type or single mutant type. This study indicated that the antifolate resistance levels of P. vivax parasites were different across China and molecular markers could be used to rapidly monitor drug resistance. Results provided evidence for updating national drug policy and treatment guidelines.

关键词： drug resistance antifolates molecular markers Plasmodium vivax China

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Metagenomic analysis on resistance genes in water and microplastics from a mariculture system

《环境科学与工程前沿（英文）》 2022年第16卷第1期页码 4-4 doi: 10.1007/s11783-021-1438-y

摘要：

Microplastics existing widely in different matrices have been regarded as a reservoir for emerging contaminants. Mariculture systems have been observed to host microplastics and antibiotic resistance genes (ARGs). However, more information on proliferation of ARGs and metal resistance genes (MRGs) in mariculture system at the presence of microplastics is needed.

关键词： Antibiotic resistance genes Metal resistance genes Metagenomic analysis Microplastics Mariculture

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Taking advantage of drug resistance, a new approach in the war on cancer

null

《医学前沿（英文）》 2018年第12卷第4期页码 490-495 doi: 10.1007/s11684-018-0647-7

摘要：

Identification of the driver mutations in cancer has resulted in the development of a new category of molecularly targeted anti-cancer drugs. However, as was the case with conventional chemotherapies, the effectiveness of these drugs is limited by the emergence of drug-resistant variants. While most cancer therapies are given in combinations that are designed to avoid drug resistance, we discuss here therapeutic approaches that take advantage of the changes in cancer cells that arise upon development of drug resistance. This approach is based on notion that drug resistance comes at a fitness cost to the cancer cell that can be exploited for therapeutic benefit. We discuss the development of sequential drug therapies in which the first therapy is not given with curative intent, but to induce a major new sensitivity that can be targeted with a second drug that selectively targets the acquired vulnerability. This concept of collateral sensitivity has hitherto not been used on a large scale in the clinic and holds great promise for future cancer therapy.

关键词： cancer drug resistance genetic screens senescence targeted therapy

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Influence evaluation of loading conditions during pressurized thermal shock transients based on thermal-hydraulics

Jinya KATSUYAMA, Shumpei UNO, Tadashi WATANABE, Yinsheng LI

《机械工程前沿（英文）》 2018年第13卷第4期页码 563-570 doi: 10.1007/s11465-018-0487-9

摘要：

The thermal hydraulic (TH) behavior of coo-lant water is a key factor in the structural integrity assessments on reactor pressure vessels (RPVs) of pressurized water reactors (PWRs) under pressurized thermal shock (PTS) events, because the TH behavior may affect the loading conditions in the assessment. From the viewpoint of TH behavior, configuration of plant equipment and their dimensions, and operator action time considerably influence various parameters, such as the temperature and flow rate of coolant water and inner pressure. In this study, to investigate the influence of the operator action time on TH behavior during a PTS event, we developed an analysis model for a typical Japanese PWR plant, including the RPV and the main components of both primary and secondary systems, and performed TH analyses by using a system analysis code called RELAP5. We applied two different operator action times based on the Japanese and the United States (US) rules: Operators may act after 10 min (Japanese rules) and 30 min (the US rules) after the occurrence of PTS events. Based on the results of TH analysis with different operator action times, we also performed structural analyses for evaluating thermal-stress distributions in the RPV during PTS events as loading conditions in the structural integrity assessment. From the analysis results, it was clarified that differences in operator action times significantly affect TH behavior and loading conditions, as the Japanese rule may lead to lower stresses than that under the US rule because an earlier operator action caused lower pressure in the RPV.

关键词： structural integrity reactor pressure vessel pressurized thermal shock thermal hydraulic analysis pressurized water reactor weld residual stress

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Assessment indices for uniform and non-uniform thermal environments

ZHANG Yufeng, SUN Shufeng, ZHAO Rongyi

《能源前沿（英文）》 2008年第2卷第2期页码 129-133 doi: 10.1007/s11708-008-0029-y

摘要： Different assessment indices for thermal environments were compared and selected for proper assessment of indoor thermal environments. 30 subjects reported their overall thermal sensation, thermal comfort, and thermal acceptability in uniform and non-uniform conditions. The results show that these three assessment indices provide equivalent evaluations in uniform environments. However, overall thermal sensation differs from the other two indices and cannot be used as a proper index for the evaluation of non-uniform environments. The relationship between the percentage and the mean vote for each index is established.

关键词： thermal sensation proper assessment relationship equivalent thermal acceptability

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Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors

《医学前沿（英文）》 2022年第16卷第5期页码 701-713 doi: 10.1007/s11684-022-0951-0

摘要： A significant clinical challenge in lung cancer treatment is management of the inevitable acquired resistance to third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKIs), such as osimertinib, which have shown remarkable success in the treatment of advanced NSCLC with EGFR activating mutations, in order to achieve maximal response duration or treatment remission. Apoptosis is a major type of programmed cell death tightly associated with cancer development and treatment. Evasion of apoptosis is considered a key hallmark of cancer and acquisition of apoptosis resistance is accordingly a key mechanism of drug acquired resistance in cancer therapy. It has been clearly shown that effective induction of apoptosis is a key mechanism for third generation EGFR-TKIs, particularly osimertinib, to exert their therapeutic efficacies and the development of resistance to apoptosis is tightly associated with the emergence of acquired resistance. Hence, restoration of cell sensitivity to undergo apoptosis using various means promises an effective strategy for the management of acquired resistance to third generation EGFR-TKIs.

关键词： acquired resistance EGFR inhibitor apoptosis lung cancer

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Liquid metal thermal hydraulics R&D at European scale: achievements and prospects

《能源前沿（英文）》 2021年第15卷第4期页码 842-853 doi: 10.1007/s11708-021-0743-2

摘要： A significant role for a future nuclear carbon-free energy production is attributed to fast reactors, mostly employing a liquid metal as a coolant. This paper summarizes the efforts that have been undertaken in collaborative projects sponsored by the European Commission in the past 20 years in the fields of liquid-metal heat transfer modeling, fuel assembly and core thermal hydraulics, pool and system thermal hydraulics, and establishment of best practice guidelines and verification, validation, and uncertainty quantification (UQ). The achievements in these fields will be presented along with the prospects on topics which will be studied collaboratively in Europe in the years to come. These prospects include further development of heat transfer models for applied computational fluid dynamics (CFD), further analysis of the consequences of fuel assembly blockages on coolant flow and temperature, analysis of the thermal hydraulic effects in deformed fuel assemblies, extended validation of three-dimensional pool thermal hydraulic CFD models, and further development and validation of multi-scale system thermal hydraulic methods.

关键词： liquid metal thermal hydraulics Europe

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Transmission of antibiotic resistance genes in agroecosystems: an overview

Jizheng HE, Zhenzhen YAN, Qinglin CHEN

《农业科学与工程前沿（英文）》 2020年第7卷第3期页码 329-332 doi: 10.15302/J-FASE-2020333

摘要：

The use of antibiotics in human medicine and animal husbandry has resulted in the continuous release of antibiotics into the environment, which imposes high selection pressure on bacteria to develop antibiotic resistance. The spread and aggregation of antibiotic resistance genes (ARGs) in multidrug-resistant pathogens is one of the most intractable clinical challenges. Numerous studies have been conducted to profile the patterns of ARGs in agricultural ecosystems, as this is closely related to human health and wellbeing. This paper provides an overview of the transmission of ARGs in agricultural ecosystems resulting from the application of animal manures and other organic amendments. The future need to control and mitigate the spread of antibiotic resistance in agricultural ecosystems is also discussed, particularly from a holistic perspective, and requires multiple sector efforts to translate fundamental knowledge into effective strategies.

关键词： agroecosystem antibiotic resistance public health soil-plant system

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swine manure with sulfamethoxazole and norfloxacin: Dynamics of microbial communities and evolution of resistance

《环境科学与工程前沿（英文）》 2021年第15卷第5期 doi: 10.1007/s11783-020-1342-x

摘要：

• SMX addition had negative effect on acetoclastic methanogens in mesophilic AD.

关键词： Pig manure Antibiotics Anaerobic digestion Resistance genes Microbial community

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Coupling evaluation for material removal and thermal control on precision milling machine tools

《机械工程前沿（英文）》 2022年第17卷第1期页码 12-12 doi: 10.1007/s11465-021-0668-9

摘要： Machine tools are one of the most representative machining systems in manufacturing. The energy consumption of machine tools has been a research hotspot and frontier for green low-carbon manufacturing. However, previous research merely regarded the material removal (MR) energy as useful energy consumption and ignored the useful energy consumed by thermal control (TC) for maintaining internal thermal stability and machining accuracy. In pursuit of energy-efficient, high-precision machining, more attention should be paid to the energy consumption of TC and the coupling relationship between MR and TC. Hence, the cutting energy efficiency model considering the coupling relationship is established based on the law of conservation of energy. An index of energy consumption ratio of TC is proposed to characterize its effect on total energy usage. Furthermore, the heat characteristics are analyzed, which can be adopted to represent machining accuracy. Experimental study indicates that TC is the main energy-consuming process of the precision milling machine tool, which overwhelms the energy consumption of MR. The forced cooling mode of TC results in a 7% reduction in cutting energy efficiency. Regression analysis shows that heat dissipation positively contributes 54.1% to machining accuracy, whereas heat generation negatively contributes 45.9%. This paper reveals the coupling effect of MR and TC on energy efficiency and machining accuracy. It can provide a foundation for energy-efficient, high-precision machining of machine tools.

关键词： machine tools cutting energy efficiency thermal stability machining accuracy coupling evaluation

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标题作者时间类型操作

A concept of capillary active, dynamic insulation integrated with heating, cooling and ventilation, air conditioning system

Mark BOMBERG

期刊论文

Distribution and removal of antibiotic resistance genes during anaerobic sludge digestion with alkaline, thermal hydrolysis and ultrasonic pretreatments

Mengli Wang, Ruying Li, Qing Zhao

期刊论文

Functional flax fiber with UV-induced switchable wettability for multipurpose oil-water separation

期刊论文

Thermal transport in organic/inorganic composites

Bin LIU, Lan DONG, Qing XI, Xiangfan XU, Jun ZHOU, Baowen LI

期刊论文

Steady-state thermal-hydraulic analysis of SCWR assembly

LIU Xiaojing, CHENG Xu

期刊论文

Prevalence of antifolate drug resistance markers in in China

期刊论文